Lydia Freddolino

(previously publishing as Peter L. Freddolino and P. Lydia Freddolino)

Associate Professor

Department of Biological Chemistry

Department of Computational Medicine and Bioinformatics


Lydia Freddolino


Ann Arbor, MI 48109-0600

Phone: 734-647-5839


Ph.D. in Biophysics and Computational Biology from the University of Illinois at Urbana-Champaign, 2009

B.S. with Honors in Biology from the California Institute of Technology, 2004

Research Interests

The regulatory networks of bacteria play a key role in their information processing capabilities, coordinating and executing interactions with their environments. Quantitative, predictive models of these networks would be tremendously beneficial for facilitating the development of new antimicrobial therapies, enabling synthetic biology applications, and understanding bacterial evolution and ecology. Ultimately, the aim of my laboratory is to build a multiscale framework enabling modeling of bacterial regulatory networks at any level of detail, from atomistic to cellular. To this end, we develop and apply high-throughput experimental methods for measuring biomolecular interactions and cellular regulatory states in vivo, and for profiling the phenotypic consequences of regulatory changes. In tandem with these experimental approaches, we use molecular simulation and mathematical modeling to obtain high-resolution insight into the biomolecular interactions driving regulatory networks, and the systems-level effects of altering them.

Professional History

2011-2014: Postdoctoral research scientist

Tavazoie Lab, Department of Systems Biology, Columbia University

2009-2011: Postdoctoral research scientist

Tavazoie Lab, Lewis-Sigler Institute for Integrative Genomics, Princeton University


See recent publications at Publications and a complete list on my Google Scholar profile

Fellowships and Awards

NIH Pathway to Independence Award (K99, 2013–2014; R00, 2015–2018)

Beckman Fellowship, University of Illinois at Urbana-Champaign, 2008-2009

National Science Foundation Graduate Research Fellowship, 2004-2009

Distinguished Fellowship, University of Illinois at Urbana-Champaign, 2004-2007

Sigma Xi Award for Undergraduate Research, California Institute of Technology, 2004 (awarded to one graduating senior each year)

President’s Scholarship, California Institute of Technology, 2000-2004