Christine A. Ziegler

Ph.D. Candidate

Department of Biological Chemistry


Christine A. Ziegler


1150 W. Medical Center Drive

Ann Arbor, MI 48109-0600


M.S. in Biological Chemistry from University of Michigan, 2018

B.S. in Chemistry with Highest Distinction from University of Rochester, 2016

B.S. in Molecular Genetics from University of Rochester, 2016

Research Interests

Regulatory mechanisms of the E. coli global regulator Lrp (leucine-responsive regulatory protein) 

Professional History

2018 to present: Graduate Research Fellow

Freddolino Lab, Department of Biological Chemistry, University of Michigan

2013 to 2016: Undergraduate Research Assistant

Fasan Lab, Department of Chemistry, University of Rochester

2015: Summer Undergraduate Research Fellow

Bassler Lab, Department of Biology, Princeton University

2014: Amgen Scholar

Miller Lab, Department of Biology, Columbia University


Ziegler, C.A. and Freddolino, P.L. (2021) The leucine-responsive regulatory proteins/feast-famine regulatory proteins: an ancient and complex class of transcriptional regulators in bacteria and archaea. Crit. Rev. Biochem. Mol. Biol. DOI: 10.1080/10409238.2021.1925215

Zamore, M.*; Ziegler, C.A.*; Freddolino, P.L.; Wolfe, A.J. (2020) A thermosensitive, phase-variable epigenetic switch: pap revisited. Microbiol. Mol. Biol. Rev. 84(3) e00030-17  

    *authors contributed equally

Owens, A.C.; Grasso, K.T.; Ziegler, C.A.; Fasan, R. (2017) Two-tier screening platform for directed evolution of amino-acyl tRNA synthetases with enhanced stop codon suppression efficiency. Chem Bio Chem. 18(12) 1109-1116

Causton, H.C.; Feeney, K.A.; Ziegler, C.A.; O’Niell, J.S. (2015) Metabolic cycles in yeast share features conserved among circadian rhythms. Curr. Biol. 25(8) 1056-1062.

Fellow ships and Awards

Rackham Predoctoral Fellowship, 2021 - 2022

NSF Graduate Research Fellowship, National Science Foundation, 2017 - 2021

NIH T32 Genetics Pre-doctoral Training Grant, National Institutes of Health, 2017 - 2019

Adam A. and Mary J. Christman Award for excellence in academic scholarship and research, Department of Biological Chemistry, 2018

Rackham Pre-candidate Graduate Reserach Fellowship, Rackham Graduate School, 2017

Bernard L. Maas Endowed Research Fellowship, Rackham Graduate School, 2016 - present

ACS Undergraduate Award in Organic Chemistry (awarded to one graduating senior), Department of Chemistry, 2016

Grace McCormack Biology Award for service to the Biology Department, Department of Biology, 2016

Aymin Amin-Salem Memorial Prize (awarded to a graduating student with the best character), Dean's Office, 2016

Certificate in Biotechnology, Department of Biology, 2016

Chemistry Junior Scholar Award, Department of Chemistry, 2015

Catherine Block Memorial Prize (awarded to the best female student in STEM each year), 2015

Dean's Scholarship, Dean's Office, 2012 - 2016