Chase Lindeboom

Education

B.S. in Biochemistry and Molecular Biology, Michigan State University, 2020

Research Interests

I am primarily interested in the interactions and co-evolution of hosts and pathogens. My current project revolves around IgA and Citrobacter rodentium (C. rodentium), a murine model of attaching and effacing enteropathogens. Recent work has shown that mice with a deficiency of IgA in the gut resist infection by and transmission of C. rodentium. The resistance stems from the failure of the C. rodentium to properly express virulence programs encoded by the locus of enterocyte effacement (LEE) pathogenicity island. This indicates that C. rodentium have evolved to somehow sense IgA and use it as a signal to express these virulence programs. Understanding the mechanisms underlying this interaction could potentially inform anti-microbial treatment against these enteropathogens by blocking their acquisition of virulence.

Professional History

2021 – present: Graduate research assistant

Freddolino and Cascalho Labs, Department of Biological Chemistry, University of Michigan

2018 – 2020: Undergraduate research assistant

Benning Lab, Department of Biochemistry and Molecular Biology, Michigan State University

2019: Perrigo undergraduate summer fellow

Cianfrocco Lab, Department of Biological Chemistry, University of Michigan

2016 – 2018: Undergraduate Professorial assistant

Jackson Lab, Department of Chemistry, Michigan State University

Publications

Takeuchi T, Sears BB, Lindeboom C, et al. Chlamydomonas CHT7 Is Required for an Effective Quiescent State by Regulating Nutrient-Responsive Cell Cycle Gene Expression. Plant Cell. 2020;32(4):1240-1269. doi:10.1105/tpc.19.00628

Fellowships and Awards

Genetics Training Program, University of Michigan, 2021 – present

Biochemistry and Molecular Biology Outstanding Undergraduate Student, Michigan State University, 2020

Dean’s List, Michigan State University, 2016 – 2020

Perrigo Fellowship, University of Michigan, 2019

Professorial Assistantship, Michigan State University, 2016 - 2018