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Tom Goss

Research Lab Specialist Senior, Biological Chemistry Department


SPC5606, 1150 W. Medical Center Drive
Ann Arbor, MI 48109-0600


PhD in Biological Chemistry from The University of Michigan, May, 1986.
BS in Biochemistry from The University of Illinois, May, 1980.

Research Interests

Cell physiology and DNA-protein interactions in bacterial systems.

Recent Publications

  • T. J. Goss, S. J. Morgan, E. L. French, and E. S. Krukonis. 2013. ToxR recognizes a direct repeat element in the toxT, ompU, ompT and ctxA promoters of Vibrio cholerae to regulate transcription. Infection and Immunity. 81:884-895. 
  • T. J. Goss, C. P. Seaborn, M. D. Gray, and E. S. Krukonis. 2010. Identification of the TcpP-binding site in the toxT promoter of Vibrio cholerae and the role of ToxR in TcpP-mediated activation. Infection and Immunity 78:4122-4133.
  • T. J. Goss. 2008. The ArgP protein stimulates the Klebsiella pneumoniae gdhA promoter in a lysine-sensitive manner. J. Bacteriol. 190:4351-4359.
  • T. J. Goss, B. K. Janes and R. A. Bender. 2002. Repression of glutamate dehydrogenase formation in Klebsiella aerogenes requires two binding sites for the nitrogen assimilation control protein, NAC. J. Bacteriol. 184:6966-6975.
  • T. J. Goss, A. Perez-Matos, and R. A. Bender. 2001. Roles of glutamate synthase, gltBD, and gltF in nitrogen metabolism of Escherichia coli and Klebsiella aerogenes. J. Bacteriol. 183:6607-6619.
  • B. K. Janes, P. J. Pomposiello, A. Perez-Matos, D. J. Najarian, T. J. Goss and R. A. Bender. 2001. Growth inhibition caused by overexpression of the structural gene for glutamate dehydrogenase (gdhA) from Klebsiella aerogenes. J. Bacteriol. 183:2709-2714.
  • L-M. Chen, T. J. Goss, R. A. Bender, S. Swift and S. Maloy. 1998. Genetic analysis, using P22 challenge phage, of the nitrogen activator protein DNA-binding site in the Klebsiella aerogenes put operon. J. Bacteriol. 180:571-577.
  • J. Feng, T. J. Goss, R. A. Bender and A. J. Ninfa. 1995. Repression of transcription initiation from the nac promoter of Klebsiella aerogenes. J. Bacteriol. 177:5523-5534.
  • J. Feng, T. J. Goss, R. A. Bender and A. J. Ninfa. 1995. Activation of the Klebsiella aerogenes nac promoter. J. Bacteriol. 177:5535-5538.
  • T. J. Goss and R. A. Bender. 1995. The nitrogen assimilation control protein, NAC, is a DNA binding transcription activator in Klebsiella aerogenes. J. Bacteriol. 177:3546-3555. 
Professional History

    11/2015 to present
        Research Lab Specialist Senior, P. L. Freddolino Lab, Biological Chemistry Department, University of Michigan

    8/2011 to 8/2014 
        Research Technician,  J. Thoene Lab, Pediatric Genetics Department, University of Michigan
    8/2008 to 8/2011 
         Research Technician, E. Krukonis Lab, Biologic and Materials Sciences Department, University of Michigan

    8/1989 to 8/2008 
        Research Specialist, R. Bender Lab,  Molecular, Cellular, and Developmental Biology Department, University of Michigan

    6/1986 to 6/1989 
        Research Fellow, M. Dilworth and A. Glenn Lab, Murdoch University, Perth, Western Australia, 6150, Australia

    1/1986 to 5/1986:
        Postdoctoral Fellow, P. Datta Lab, Biological Chemistry Department, University of Michigan

    9/1980 to 12/1985 
        Graduate student, P. Datta Lab, Biological Chemistry Department, University of Michigan