3315 MSRB III
SPC5606, 1150 W. Medical Center Drive
Ann Arbor, MI 48109-0600
mbwolfe@umich.edu

My primary research interests are in the global regulation of gene expression, particularly at the post-transcriptional level. More specifically, I am interested in determining global RNA-protein and RNA-RNA interactions within Escherichia coli under different stress conditions and developing mathematical models to explain changes in the interaction patterns seen. I hope to accomplish this through the combination of novel RNA-complex purification methods developed in the Freddolino lab, the use of modern high throughput sequencing, and subsequent bioinformatic analysis. Applications of this research include: better understanding of the regulatory logic that underlies complex biological systems, a deeper understanding of the factors involved in the development of bacterial antibiotic resistance, and the ultimate goal of developing a working model of a living organism from the molecular to systems-level scale.

    2015 to Present:

        Graduate Research Assistant, Freddolino Lab, Biological Chemistry Department, University of Michigan

    2010 to 2014 

        Undergraduate Research Assistant, Jackman Lab, Department of Chemistry and Biochemistry, Ohio State University