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Michael Wolfe

Ph.D. Candidate, Biological Chemistry Department


SPC5606, 1150 W. Medical Center Drive
Ann Arbor, MI 48109-0600


B.S. in Biomedical Engineering from Ohio State University, 2014

Research Interests

My primary research interests are in the global regulation of gene expression, particularly at the post-transcriptional level. More specifically, I am interested in determining global RNA-protein and RNA-RNA interactions within Escherichia coli under different stress conditions and developing mathematical models to explain changes in the interaction patterns seen. I hope to accomplish this through the combination of novel RNA-complex purification methods developed in the Freddolino lab, the use of modern high throughput sequencing, and subsequent bioinformatic analysis. Applications of this research include: better understanding of the regulatory logic that underlies complex biological systems, a deeper understanding of the factors involved in the development of bacterial antibiotic resistance, and the ultimate goal of developing a working model of a living organism from the molecular to systems-level scale.

Professional History

    2015 to Present:
        Graduate Research Assistant, Freddolino Lab, Biological Chemistry Department, University of Michigan

    2010 to 2014 
        Undergraduate Research Assistant, Jackman Lab, Department of Chemistry and Biochemistry, Ohio State University

Fellowships and Awards

National Science Foundation Graduate Research Fellow
Ann Arbor, MI
April 2015 - Present

Detroit Zoo Fellowship in Science Communication
Royal Oaks, MI
October 2014- Present

Bernard L. Maas Endowed Medical Fellowship Awardee 
Ann Arbor, MI
September 2014- Present

National Science Foundation Graduate Research Fellowship Honorable Mention 
Columbus, OH
March 2014- April 2015

Arnold and Mabel Beckman Foundation Scholar 
Columbus, OH
March 2011- August 2012