Lydia Freddolino
(formerly Peter L. Freddolino; publishing as P. Lydia Freddolino)
Associate Professor
Department of Biological Chemistry
Department of Computational Medicine and Bioinformatics
Contact
Lydia Freddolino
3301E MSRB III
Ann Arbor, MI 48109-0600
Phone: 734-647-5839
Education
Ph.D. in Biophysics and Computational Biology from the University of Illinois at Urbana-Champaign, 2009
B.S. with Honors in Biology from the California Institute of Technology, 2004
Research Interests
The regulatory networks of bacteria play a key role in their information processing capabilities, coordinating and executing interactions with their environments. Quantitative, predictive models of these networks would be tremendously beneficial for facilitating the development of new antimicrobial therapies, enabling synthetic biology applications, and understanding bacterial evolution and ecology. Ultimately, the aim of my laboratory is to build a multiscale framework enabling modeling of bacterial regulatory networks at any level of detail, from atomistic to cellular. To this end, we develop and apply high-throughput experimental methods for measuring biomolecular interactions and cellular regulatory states in vivo, and for profiling the phenotypic consequences of regulatory changes. In tandem with these experimental approaches, we use molecular simulation and mathematical modeling to obtain high-resolution insight into the biomolecular interactions driving regulatory networks, and the systems-level effects of altering them.
Professional History
2011-2014: Postdoctoral research scientist
Tavazoie Lab, Department of Systems Biology, Columbia University
2009-2011: Postdoctoral research scientist
Tavazoie Lab, Lewis-Sigler Institute for Integrative Genomics, Princeton University
Publications
See recent publications at Publications and a complete list on my Google Scholar profile
Fellowships and Awards
NIH Pathway to Independence Award (K99, 2013–2014; R00, 2015–2018)
Beckman Fellowship, University of Illinois at Urbana-Champaign, 2008-2009
National Science Foundation Graduate Research Fellowship, 2004-2009
Distinguished Fellowship, University of Illinois at Urbana-Champaign, 2004-2007
Sigma Xi Award for Undergraduate Research, California Institute of Technology, 2004 (awarded to one graduating senior each year)
President’s Scholarship, California Institute of Technology, 2000-2004