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Christine A. Ziegler

Ph.D. Candidate, Department of Biological Chemistry

1150 W. Medical Center Drive
Ann Arbor, MI 48109-0600

M.S. in Biological Chemistry from University of Michigan, 2018
B.S. in Chemistry with Highest Distinction from University of Rochester, 2016
B.S. in Molecular Genetics from University of Rochester, 2016

Professional History
    2018 to present:
        Graduate Research Fellow, Freddolino Lab, Department of Biological Chemistry, University of Michigan
        Major research interest: Regulatory mechanisms of the E. coli global regulator Lrp (leucine-responsive regulatory protein) 

    2013 to 2016:
        Undergraduate Research Assistant, Fasan Lab, Department of Chemistry, University of Rochester
        Major research interest: Evolution of aminoacyl tRNA synthetases for the incorporation of lysine-derived unnatural amino acids into proteins via amber             stop codon suppression
        Summer Undergraduate Research Fellow, Bassler Lab, Department of Biology, Princeton University
        Major research interest: Quorum sensing in Vibrio harveyii

        Amgen Scholar, Miller Lab, Department of Biology, Columbia University
        Major research interest: Ultradian rhythms in S. pombe


Ziegler, C.A. and Freddolino, P.L. (2021) The leucine-responsive regulatory proteins/feast-famine regulatory proteins: an ancient and complex class of transcriptional regulators in bacteria and archaea. Crit. Rev. Biochem. Mol. Biol. DOI: 10.1080/10409238.2021.1925215

Zamore, M.*; Ziegler, C.A.*; Freddolino, P.L.; Wolfe, A.J. (2020) A thermosensitive, phase-variable epigenetic switch: pap revisited. Microbiol. Mol. Biol. Rev. 84(3) e00030-17  

    *authors contributed equally

Owens, A.C.; Grasso, K.T.; Ziegler, C.A.; Fasan, R. (2017) Two-tier screening platform for directed evolution of amino-acyl tRNA synthetases with enhanced stop codon suppression efficiency. Chem Bio Chem. 18(12) 1109-1116

Causton, H.C.; Feeney, K.A.; Ziegler, C.A.; O’Niell, J.S. (2015) Metabolic cycles in yeast share features conserved among circadian rhythms. Curr. Biol. 25(8) 1056-1062.

Fellowships and Awards
National Fellowships:
         - NIH T32 Genetics Pre-doctoral Training Grant, National Institutes of Health, 2017 - 2019
         - NSF Graduate Research Fellowship, National Science Foundation, 2017 - 2021

University of Michigan (2016 - present):
        - Rackham Predoctoral Fellowship, 2021 - 2022
        - Adam A. and Mary J. Christman Award for excellence in academic scholarship and research, Department of Biological Chemistry, 2018
        - Rackham Pre-candidate Graduate Reserach Fellowship, Rackham Graduate School, 2017
        - Bernard L. Maas Endowed Research Fellowship, Rackham Graduate School, 2016 - present

University of Rochester (2012 - 2016):
        - ACS Undergraduate Award in Organic Chemistry (awarded to one graduating senior), Department of Chemistry, 2016
        - Grace McCormack Biology Award for service to the Biology Department, Department of Biology, 2016
        - Aymin Amin-Salem Memorial Prize (awarded to a graduating student with the best character), Dean's Office, 2016
        - Certificate in Biotechnology, Department of Biology, 2016
        - Chemistry Junior Scholar Award, Department of Chemistry, 2015
        - Catherine Block Memorial Prize (awarded to the best female student in STEM each year), 2015
        - Dean's Scholarship, Dean's Office, 2012 - 2016

Honors Societies:
        - Sigma Xi, member since 2017 
        - Phi Beta Kappa, member since 2016